Data Sharing for Next Generation Sequencing

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0% COMPLETE

Data Sharing for Next Generation Sequencing

Course Outline

Overview
Course Introduction
Why Is It Important to Share NGS Data?
NGS data repositories and dbGaP
Conclusion
Sharing Overview & Environment
Section Overview
When is Data Sharing Required?
Methods of Sharing Data
Exceptions to Data Submission Expectations
Choosing a Data Repository
About dbGaP
Conclusion
Incorporating Sharing into the NGS Core activities framework
Section Overview
Preparing for Sharing Throughout the NGS Framework
Formulation Preparations
Approval Preparations
Preparations: Laboratory Work
Experimentation and Data Analysis Pipeline
Publication: Submitting Data to a Repository
Conclusion
Preparation for Sharing: Formulation, Approvals, Library Preparations
Section Overview
NIH Data Sharing Plans
Genomic Data Sharing DSP Element 1: Data Type
GDS DSP Element 2: Data Repository
GDS DSP Element 3: Data Submission and Release Timeline
GDS DSP Elements 4-6: IRB Approval, Use
Implementing and Expanding the Data Sharing Plan
Approval Stage: IRB and Consent Forms
Assembling a Research Team
Conclusion
Manage your data
Section Overview
Storage Management for Sharing Data
Documentation and Metadata for Shared Data
Library Preparation Documentation and Metadata
Documenting and Managing Files from Core Facilities
Experimentation and Analysis Examples
File-Level Metadata
File Organization, Reorganization, and Symbolic Links
Scripting for Preparing Files for Repositories
Security of NGS Files
Conclusion
Share Your Data
Section Overview
The Publication Stage of the NGS Framework
Deciding What to Deposit to dbGaP
dbGaP Submission Process Overview
The Study Configuration File
Subject IDs, Subject Consent File, and Pedigree File
Subject Phenotype and Sample Attribute Files
Molecular Data File
Final Steps in Submitting Documentation and Transferring Files
Removing Direct Identifiers for dbGaP Submissions
Linking Publications to Associated Data
Conclusion and Credits

Data Sharing for Next Generation Sequencing

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